Description
Delta Sleep-Inducing Peptide (DSIP): Functions and Discovery
Delta sleep-inducing peptide (DSIP) is an amphiphilic peptide with a molecular weight of 850 daltons, characterized by the amino acid motif N-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-C.
Initially discovered in 1974 by the Swiss Schoenenberger-Monnier group, DSIP was isolated from the cerebral venous blood of rabbits in a sleep-induced state. While initially believed to regulate sleep due to its ability to induce slow-wave sleep in rabbits, research findings on its role in sleep regulation have been inconsistent.
DSIP is found in both free and bound forms in various parts of the body, including the hypothalamus, limbic system, pituitary, and peripheral organs. In the pituitary, it co-localizes with numerous peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH), and melanin-concentrating hormone (MCH). It is also abundant in gut secretory cells and pancreatic tissues, where it co-localizes with glucagon.
- Delta Sleep-Inducing Peptide (DSIP)
- Sleep regulation peptide
- Hypothalamus function
- Slow-wave sleep induction
- Peptide discovery and functions