Description
Prohibitin-Targeting Peptide 1 (TP01): A Potential Antineoplastic Agent
Prohibitin-Targeting Peptide 1 (prohibitin-TP01) is a chimeric, 25-mer peptide with promising antineoplastic activity. This peptide targets prohibitin in white adipose tissue and consists of a fat-targeting motif (CKGGRAKDC), two repeats of a proapoptotic peptide motif (KLAKLAK), and a GG linker.
Prohibitin-TP01 binds specifically to prohibitin within the white adipose vasculature. Upon receptor-mediated internalization, the ligand/receptor complex induces apoptosis, leading to the ablation of white fat. This reduction in white fat is particularly beneficial for men with prostate cancer, as high levels of white fat are associated with poor cancer outcomes.
Prohibitin is a multifunctional, membrane-associated protein that regulates cell survival and growth. Immunohistochemical analysis has shown that prohibitin is expressed in the endothelial cell membranes of white adipose tissue. For more information, including active or closed clinical trials using this agent, refer to the latest research updates.
- Prohibitin-targeting peptide
- Antineoplastic activity peptide
- Prohibitin-TP01 prostate cancer
- White adipose tissue apoptosis
- Prohibitin endothelial cell membrane